we performed single-cell transcriptomes of 88,622 cells derived from 15 tissue organs of one adult donor and generated an adult human cell atlas (AHCA).
首先是 a total of 20,494 T cells,可以区分成为 CD4+ (7,122) and CD8+ (13,372) T cells 两个大类,然后继续每个大类细分为11 and 22细胞亚群。
然后是7,137个 Endothelial cells (ECs) 细胞, including 6,863 blood endothelial cells (BECs, marked with VWF) and 274 lymphatic endothelial cells (LECs, marked with LYVE1).
最后是 a total of 17,835 fibroblasts and smooth muscle cells , 分成
14 fibroblast clusters (11,767 cells, MMP2),
four smooth muscle cell clusters (3,201 cells, ACTA2),
another five clusters assigned as FibSmo (2,867 cells; marked with MMP2 and ACTA2; )
单细胞测序的肺癌肿瘤免疫微环境中基质细胞
文章是:Phenotype molding of stromal cells in the lung tumor microenvironment。
基本上也是细胞分群后继续分群,文献里面公布的主要亚群标记基因是:
endothelial cells:CLDN18, FOLR1, AQP4 and PEBP4
endothilial:CLDN5, FLT1, CDH5 ,RAMP2
epithelial cells: CAPS, TMEM190, PIFO,SNTN
fibroblasts,COL1A1, Decorin (DCN) Collagen type I alpha 2 (COL1A2) and C1R 9 ; B-cells,:genes encoding the B-cell antigen receptor complex-associated protein alpha (CD79A),Immunoglobulin Kappa Constant (IGKC), Immunoglobulin Lambda Constant 3 (IGLC3) and Immunoglobulin Heavy Constant Gamma 3 (IGHG3)
myeloid cells, genes encoding Lysozyme (LYZ), the Macrophage Receptor With Collagenous Structure (MARCO), CD68 and CD16a, the Fc Fragment Of IgG Receptor IIIa (FCGR3A) 10