blocks|key|267162|text|尝试在configuration节点下的app.config中使用这个确切的启动标记|type|unstyled|depth|inlineStyleRanges|entityRanges|data|267163|<startup+useLegacyV2RuntimeActivationPolicy="true">
++++<supportedRuntime+version="v4.0"+sku=".NETFramework,Version=v4.0"/>
++++<requiredRuntime+version="v4.0.20506"+/>
++</startup>|code-block|syntax|javascript|267164|entityMap^0|0|0^^$0|@$1|2|3|4|5|6|7|I|8|@]|9|@]|A|$]]|$1|B|3|C|5|D|7|J|8|@]|9|@]|A|$E|F]]|$1|G|3|-4|5|6|7|K|8|@]|9|@]|A|$]]]|H|$]]

Try to use this exact startup tag in your app.config under configuration node

<pre><code>&lt;startup useLegacyV2RuntimeActivationPolicy="true"&gt;
 &lt;supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.0"/&gt;
 &lt;requiredRuntime version="v4.0.20506" /&gt;
 &lt;/startup&gt;
</code></pre>

blocks|key|265611|text|尝试使用其他配置文件(不是项目中的配置文件)并重新启动Visual+Studio：|type|unstyled|depth|inlineStyleRanges|entityRanges|data|265612|C:\Program+Files+(x86)\Microsoft+Visual+Studio+11.0\Common7\IDE\CommonExtensions\Microsoft\TestWindow\vstest.executionengine.x86.exe.config
(32-bit)|code-block|syntax|javascript|265613|或|265614|C:\Program+Files+(x86)\Microsoft+Visual+Studio+11.0\Common7\IDE\CommonExtensions\Microsoft\TestWindow\vstest.executionengine.exe.config
(64-bit)|265615|entityMap^0|0|0|0|0^^$0|@$1|2|3|4|5|6|7|M|8|@]|9|@]|A|$]]|$1|B|3|C|5|D|7|N|8|@]|9|@]|A|$E|F]]|$1|G|3|H|5|6|7|O|8|@]|9|@]|A|$]]|$1|I|3|J|5|D|7|P|8|@]|9|@]|A|$E|F]]|$1|K|3|-4|5|6|7|Q|8|@]|9|@]|A|$]]]|L|$]]

Try to use another config file (not the one from your project) and RESTART Visual Studio:

<pre><code>C:\Program Files (x86)\Microsoft Visual Studio 11.0\Common7\IDE\CommonExtensions\Microsoft\TestWindow\vstest.executionengine.x86.exe.config
(32-bit)
</code></pre>

or

<pre><code>C:\Program Files (x86)\Microsoft Visual Studio 11.0\Common7\IDE\CommonExtensions\Microsoft\TestWindow\vstest.executionengine.exe.config
(64-bit)
</code></pre>

blocks|key|263966|text|实际上，我在逆解中遇到了同样的问题。我将一个.NET项目升级到了.NET+4.0，然后又恢复到了.NET+3.5。我的项目中的app.config仍然有以下导致上述错误的原因：|type|unstyled|depth|inlineStyleRanges|entityRanges|data|263967|<startup>
++<supportedRuntime+version="v4.0"+sku=".NETFramework,Version=v4.0"/>
</startup>|code-block|syntax|javascript|263968|解决此错误的解决方案是将其恢复为正确的2.0引用，如下所示：|263969|<startup>
++<supportedRuntime+version="v2.0.50727"/>
</startup>|263970|因此，如果降级产生上述错误，您可能需要备份.NET框架支持的版本。|263971|entityMap^0|0|0|0|0|0^^$0|@$1|2|3|4|5|6|7|O|8|@]|9|@]|A|$]]|$1|B|3|C|5|D|7|P|8|@]|9|@]|A|$E|F]]|$1|G|3|H|5|6|7|Q|8|@]|9|@]|A|$]]|$1|I|3|J|5|D|7|R|8|@]|9|@]|A|$E|F]]|$1|K|3|L|5|6|7|S|8|@]|9|@]|A|$]]|$1|M|3|-4|5|6|7|T|8|@]|9|@]|A|$]]]|N|$]]

I actually had this identical issue with the inverse solution. I had upgraded a .NET project to .NET 4.0 and then reverted back to .NET 3.5. The app.config in my project continued to have the following which was causing the above error in question:

<pre><code>&lt;startup&gt;
 &lt;supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.0"/&gt;
&lt;/startup&gt;
</code></pre>

The solution to solve the error for this was to revert it back to the proper 2.0 reference as follows:

<pre><code>&lt;startup&gt;
 &lt;supportedRuntime version="v2.0.50727"/&gt;
&lt;/startup&gt;
</code></pre>

So if a downgrade is producing the above error, you might need to back up the .NET Framework supported version.

blocks|key|3171068|text|该异常清楚地标识了.NET+4.0中包含的某些.NET+2.0.50727组件。在App.config文件中使用以下命令：|type|unstyled|depth|inlineStyleRanges|entityRanges|data|3171069|<startup+useLegacyV2RuntimeActivationPolicy="true"+/>+|code-block|syntax|javascript|3171070|它解决了我的问题|3171071|entityMap^0|0|0|0^^$0|@$1|2|3|4|5|6|7|K|8|@]|9|@]|A|$]]|$1|B|3|C|5|D|7|L|8|@]|9|@]|A|$E|F]]|$1|G|3|H|5|6|7|M|8|@]|9|@]|A|$]]|$1|I|3|-4|5|6|7|N|8|@]|9|@]|A|$]]]|J|$]]

The exception clearly identifies some .NET 2.0.50727 component was included in .NET 4.0. In App.config file use this:

<pre><code>&lt;startup useLegacyV2RuntimeActivationPolicy="true" /&gt; 
</code></pre>

It solved my problem

blocks|key|3171108|text|对我来说，这是在MSTest+(VS2015)下运行单元测试时抛出的。必须添加|type|unstyled|depth|inlineStyleRanges|offset|length|style|CODE|entityRanges|data|3171109|<startup+useLegacyV2RuntimeActivationPolicy="true">
</startup>|code-block|syntax|javascript|3171110|在……里面|3171111|C:\Program+Files+(x86)\Microsoft+Visual+Studio+14.0\Common7\IDE\CommonExtensions\Microsoft\TestWindow\TE.ProcessHost.Managed.exe.config|3171112|Mixed-Mode+Assembly+MSTest+Failing+in+VS2015|3171113|entityMap|0|LINK|mutability|MUTABLE|url|https://stackoverflow.com/questions/32478917/mixed-mode-assembly-mstest-failing-in-vs2015^0|8|6|0|0|0|0|3R|0|0|18|0|0^^$0|@$1|2|3|4|5|6|7|Y|8|@$9|Z|A|10|B|C]]|D|@]|E|$]]|$1|F|3|G|5|H|7|11|8|@]|D|@]|E|$I|J]]|$1|K|3|L|5|6|7|12|8|@]|D|@]|E|$]]|$1|M|3|N|5|6|7|13|8|@$9|14|A|15|B|C]]|D|@]|E|$]]|$1|O|3|P|5|6|7|16|8|@]|D|@$9|17|A|18|1|19]]|E|$]]|$1|Q|3|-4|5|6|7|1A|8|@]|D|@]|E|$]]]|R|$S|$5|T|U|V|E|$W|X]]]]

For me this was thrown when running unit tests under <code>MSTest</code> (VS2015). Had to add 

<pre><code>&lt;startup useLegacyV2RuntimeActivationPolicy="true"&gt;
&lt;/startup&gt;
</code></pre>

in 

<code>C:\Program Files (x86)\Microsoft Visual Studio 14.0\Common7\IDE\CommonExtensions\Microsoft\TestWindow\TE.ProcessHost.Managed.exe.config</code>

<a href="https://stackoverflow.com/questions/32478917/mixed-mode-assembly-mstest-failing-in-vs2015">Mixed-Mode Assembly MSTest Failing in VS2015</a>

blocks|key|2957132|text|请在您的应用程序app.config文件中添加属性useLegacyV2RuntimeActivationPolicy="true“。|type|unstyled|depth|inlineStyleRanges|entityRanges|data|2957133|旧值|offset|length|style|BOLD|2957134|++<startup>
++++<supportedRuntime+version="v4.0"+sku=".NETFramework,Version=v4.5.1"/>
++</startup>|code-block|syntax|javascript|2957135|新值|2957136|++<startup+useLegacyV2RuntimeActivationPolicy="true">
++++<supportedRuntime+version="v4.0"+sku=".NETFramework,Version=v4.5.1"/>
++</startup>|2957137|它会解决你的问题。|2957138|entityMap^0|0|0|2|0|0|0|2|0|0|0^^$0|@$1|2|3|4|5|6|7|U|8|@]|9|@]|A|$]]|$1|B|3|C|5|6|7|V|8|@$D|W|E|X|F|G]]|9|@]|A|$]]|$1|H|3|I|5|J|7|Y|8|@]|9|@]|A|$K|L]]|$1|M|3|N|5|6|7|Z|8|@$D|10|E|11|F|G]]|9|@]|A|$]]|$1|O|3|P|5|J|7|12|8|@]|9|@]|A|$K|L]]|$1|Q|3|R|5|6|7|13|8|@]|9|@]|A|$]]|$1|S|3|-4|5|6|7|14|8|@]|9|@]|A|$]]]|T|$]]

Please add attribute useLegacyV2RuntimeActivationPolicy="true" in your applications app.config file.

Old Value

<pre><code> &lt;startup&gt;
 &lt;supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.5.1"/&gt;
 &lt;/startup&gt;
</code></pre>

New Value

<pre><code> &lt;startup useLegacyV2RuntimeActivationPolicy="true"&gt;
 &lt;supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.5.1"/&gt;
 &lt;/startup&gt;
</code></pre>

It will solve your problem.

blocks|key|261805|text|启用来自app.config的遗留功能对我来说不起作用。由于未知的原因，我的应用程序没有激活V2运行时策略。我在here附近找到了一个工作。|type|unstyled|depth|inlineStyleRanges|entityRanges|offset|length|data|261806|从app.config启用遗留功能是一种推荐的方法，但在某些情况下，它不会像预期的那样工作。在您的主应用程序中使用以下代码来强制使用旧版V2策略：|261807|public+static+class+RuntimePolicyHelper
{
public+static+bool+LegacyV2RuntimeEnabledSuccessfully+{+get;+private+set;+}

static+RuntimePolicyHelper()
{
++++ICLRRuntimeInfo+clrRuntimeInfo+=
++++++++(ICLRRuntimeInfo)RuntimeEnvironment.GetRuntimeInterfaceAsObject(
++++++++++++Guid.Empty,+
++++++++++++typeof(ICLRRuntimeInfo).GUID);
++++try
++++{
++++++++clrRuntimeInfo.BindAsLegacyV2Runtime();
++++++++LegacyV2RuntimeEnabledSuccessfully+=+true;
++++}
++++catch+(COMException)
++++{
++++++++//+This+occurs+with+an+HRESULT+meaning+
++++++++//+"A+different+runtime+was+already+bound+to+the+legacy+CLR+version+2+activation+policy."
++++++++LegacyV2RuntimeEnabledSuccessfully+=+false;
++++}
}

[ComImport]
[InterfaceType(ComInterfaceType.InterfaceIsIUnknown)]
[Guid("BD39D1D2-BA2F-486A-89B0-B4B0CB466891")]
private+interface+ICLRRuntimeInfo
{
++++void+xGetVersionString();
++++void+xGetRuntimeDirectory();
++++void+xIsLoaded();
++++void+xIsLoadable();
++++void+xLoadErrorString();
++++void+xLoadLibrary();
++++void+xGetProcAddress();
++++void+xGetInterface();
++++void+xSetDefaultStartupFlags();
++++void+xGetDefaultStartupFlags();

++++[MethodImpl(MethodImplOptions.InternalCall,+MethodCodeType+=+MethodCodeType.Runtime)]
++++void+BindAsLegacyV2Runtime();
}
}|code-block|syntax|javascript|261808|entityMap|0|LINK|mutability|MUTABLE|url|http://reedcopsey.com/2011/09/15/setting-uselegacyv2runtimeactivationpolicy-at-runtime/^0|1K|4|0|0|0|0^^$0|@$1|2|3|4|5|6|7|S|8|@]|9|@$A|T|B|U|1|V]]|C|$]]|$1|D|3|E|5|6|7|W|8|@]|9|@]|C|$]]|$1|F|3|G|5|H|7|X|8|@]|9|@]|C|$I|J]]|$1|K|3|-4|5|6|7|Y|8|@]|9|@]|C|$]]]|L|$M|$5|N|O|P|C|$Q|R]]]]

Enabling the legacy from app.config didn't work for me. For unknown reasons, my application wasn't activating V2 runtime policy. I found a work around <a href="http://reedcopsey.com/2011/09/15/setting-uselegacyv2runtimeactivationpolicy-at-runtime/" rel="nofollow noreferrer">here</a>.

Enabling the legacy from app.config is a recommended approach but in some cases it doesn't work as expected. Use the following code with in your main application to force Legacy V2 policy:

<pre><code>public static class RuntimePolicyHelper
{
public static bool LegacyV2RuntimeEnabledSuccessfully { get; private set; }

static RuntimePolicyHelper()
{
 ICLRRuntimeInfo clrRuntimeInfo =
 (ICLRRuntimeInfo)RuntimeEnvironment.GetRuntimeInterfaceAsObject(
 Guid.Empty, 
 typeof(ICLRRuntimeInfo).GUID);
 try
 {
 clrRuntimeInfo.BindAsLegacyV2Runtime();
 LegacyV2RuntimeEnabledSuccessfully = true;
 }
 catch (COMException)
 {
 // This occurs with an HRESULT meaning 
 // "A different runtime was already bound to the legacy CLR version 2 activation policy."
 LegacyV2RuntimeEnabledSuccessfully = false;
 }
}

[ComImport]
[InterfaceType(ComInterfaceType.InterfaceIsIUnknown)]
[Guid("BD39D1D2-BA2F-486A-89B0-B4B0CB466891")]
private interface ICLRRuntimeInfo
{
 void xGetVersionString();
 void xGetRuntimeDirectory();
 void xIsLoaded();
 void xIsLoadable();
 void xLoadErrorString();
 void xLoadLibrary();
 void xGetProcAddress();
 void xGetInterface();
 void xSetDefaultStartupFlags();
 void xGetDefaultStartupFlags();

 [MethodImpl(MethodImplOptions.InternalCall, MethodCodeType = MethodCodeType.Runtime)]
 void BindAsLegacyV2Runtime();
}
}
</code></pre>

blocks|key|267292|text|如果错误发生，错误列“文件”为SGEN，那么修复需要在sgen.exe旁边的文件sgen.exe.config中。例如，对于VS+2015，创建C:\Program+Files+(x86)\Microsoft+SDKs\Windows\v10.0A\bin\NETFX+4.6+Tools\sgen.exe.config。最小文件内容：<configuration><startup+useLegacyV2RuntimeActivationPolicy="true"/></configuration>|type|unstyled|depth|inlineStyleRanges|offset|length|style|CODE|entityRanges|data|267293|来源：SGEN+Mixed+mode+assembly|267294|entityMap|0|LINK|mutability|MUTABLE|url|https://support.microsoft.com/en-us/help/2572158/sgen-mixed-mode-assembly-is-built-against-version-v2-0-50727-of-the-ru^0|R|8|14|F|20|2G|4O|2B|0|3|O|0|0^^$0|@$1|2|3|4|5|6|7|P|8|@$9|Q|A|R|B|C]|$9|S|A|T|B|C]|$9|U|A|V|B|C]|$9|W|A|X|B|C]]|D|@]|E|$]]|$1|F|3|G|5|6|7|Y|8|@]|D|@$9|Z|A|10|1|11]]|E|$]]|$1|H|3|-4|5|6|7|12|8|@]|D|@]|E|$]]]|I|$J|$5|K|L|M|E|$N|O]]]]

If the error happens with error column "File" as SGEN, then the fix needs to be in a file <code>sgen.exe.config</code>, next to <code>sgen.exe</code>. For example, for VS 2015, create <code>C:\Program Files (x86)\Microsoft SDKs\Windows\v10.0A\bin\NETFX 4.6 Tools\sgen.exe.config</code>. Minimum file contents: <code>&lt;configuration&gt;&lt;startup useLegacyV2RuntimeActivationPolicy="true"/&gt;&lt;/configuration&gt;</code>

Source: <a href="https://support.microsoft.com/en-us/help/2572158/sgen-mixed-mode-assembly-is-built-against-version-v2-0-50727-of-the-ru" rel="nofollow noreferrer">SGEN Mixed mode assembly</a>

I'm getting the following exception:

<blockquote>
 Mixed mode assembly is built against version ‘v2.0.50727′ of the runtime and cannot be loaded in the 4.0 runtime without additional configuration information.
</blockquote>

as I was trying to export crystal report from my WPF program... 

I have added the following in the app.config already...

<pre><code>&lt;startup useLegacyV2RuntimeActivationPolicy="true"&gt;
 &lt;supportedRuntime version="v4.0" sku=".NETFramework,Version=v4.0"/&gt;
&lt;/startup&gt;
&lt;runtime&gt;
 &lt;NetFx40_LegacySecurityPolicy enabled="true"/&gt;
&lt;/runtime&gt;
</code></pre>

Any experts can help????

Reference I found: 
<a href="http://www.davidmoore.info/2010/12/17/running-net-2-runtime-applications-under-the-net-4-runtime" rel="noreferrer">http://www.davidmoore.info/2010/12/17/running-net-2-runtime-applications-under-the-net-4-runtime</a>

Mixed mode assembly is built against version ‘v2.0.50727′ of the runtime

Visual Studio

单元测试

Windows

我得到了以下异常：混合模式程序集是针对运行时版本‘v2.0.50727’构建的，如果没有其他配置信息，则无法在4.0运行时中加载该程序集。当我试图从我的WPF程序中导出水晶报表时...我已经在app.config中添加了以下内容...<startup useLegacyV2RuntimeActivationPolicy...

问混合模式程序集是针对运行时版本‘v2.0.50727’构建的
EN

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