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微生物与癌症的关系

Cancer-microbe associations have been explored for centuries, but cancer-associated fungi have rarely been examined. Here, we comprehensively characterize the cancer mycobiome within 17,401 patient tissue, blood, and plasma samples across 35 cancer types in four independent cohorts. We report fungal DNA and cells at low abundances across many major human cancers, with differences in community compositions that differ among cancer types, even when accounting for technical background. Fungal histological staining of tissue microarrays supported intratumoral presence and frequent spatial association with cancer cells and macrophages. Comparing intratumoral fungal communities with matched bacteriomes and immunomes re- vealed co-occurring bi-domain ecologies, often with permissive, rather than competitive, microenvironments and distinct immune responses. Clinically focused assessments suggested prognostic and diagnostic ca- pacities of the tissue and plasma mycobiomes, even in stage I cancers, and synergistic predictive perfor- mance with bacteriomes.

微生物菌群的单细胞组学

单细胞微生物2022-Science-High-throughput, single-microbe genomics with strain resolution applied to a human gut microbiome

单细胞微生物2022-Cell-Single-cell approaches in human microbiome research