文章对人胎儿视网膜和hESC来源的视网膜organoid进行了scATAC-seq，包括7个胎儿视网膜（其中2个在体外培养了4天）和5个organoid样本，根据年龄的不同，包含大约10-20个organoids...Fig4 想看organoid多大程度和胚胎发育过程相似，比较了 organoid和胚胎来源培养的视网膜球（分群的不同、peaks的基因通路富集、和scRNAseq数据整合分析）。...视网膜organoid的染色质可及性 Fig4 organoid和视网膜球(reinospheres)的比较 organoid 里的细胞群和胚胎样本中的很相似。...接着分析比较了我们组之前发表的scRNAseq数据 , NOTCH信号通路的组分在organoid中表达很低 (Fig4D), AC和HC 的细胞数量在organoid中有降低 (Fig4E-F)。...Fig6 视网膜organoid添加 Notch 抑制剂后染色质开放性的变化 接着又在视网膜organoid中检测Notch抑制剂的作用。
_Organoid.txt.gz GSM2653842_Counts_notmergedTR_CHC1_Organoid_1.txt.gz GSM2653843_Counts_notmergedTR_CHC1..._Organoid_b.txt.gz GSM2653846_Counts_notmergedTR_CHC2_Organoid.txt.gz GSM2653847_Counts_notmergedTR_CC1..._Organoid_1.txt.gz GSM2653848_Counts_notmergedTR_CC1_Organoid_2.txt.gz GSM2653849_Counts_notmergedTR_CC1..._Organoid_a.txt.gz GSM2653850_Counts_notmergedTR_CC1_Organoid_b.txt.gz GSM2653851_Counts_notmergedTR_CC1..._Organoid_c.txt.gz GSM2653852_Counts_notmergedTR_CC2_Organoid.txt.gz GSM2653853_Counts_notmergedTR_CC3
文章标题是：Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients ,研究人员利用由癌症患者肿瘤衍生出的三维...共制备成功了22个orgnoid： We successfully generated organoid cultures from 22 of 27 tumor samples....RNA from 22 organoid tumor samples and 15 paired normal samples was hybridized on Affymetrix Human Gene...是37个样本 single organoid RNA-seq data is GEO: GSE65253....学徒作业 因为作者上传了单细胞表达矩阵，single organoid RNA-seq data is GEO: GSE65253. 是108个样本。 ?
Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies....Organoid Modeling of the Tumor Immune Microenvironment....Cancer modeling meets human organoid technology....Organoid models of gastrointestinal cancers in basic and translational research....Organoid cultures derived from patients with advanced prostate cancer.
Coining the term “organoid intelligence” (OI) to encompass these developments, we present a collaborative...Technologies that could enable novel biocomputing models via stimulus-response training and organoid-computer...‘Organoid intelligence’ (OI) describes an emerging multidisciplinary field working to develop biological...In this article, we describe the emerging field that we term “organoid intelligence” (OI), which aims
Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity》 2018的Cancer Discovery杂志：《Organoid...chemotherapy in pancreatic cancer》 2018的cell杂志：《Tumor Evolution and Drug Response in Patient-Derived Organoid...Models of Bladder Cancer》 2018的Cell Stem Cell：《A Comprehensive Human Gastric Cancer Organoid Biobank
acc=GSE84073 对应的文章是：uman primary liver cancer-derived organoid cultures for disease modeling and drug...Tissue.txt.gz GSM2653822_Counts_notmergedTR_Healthy3_Tissue.txt.gz GSM2653833_Counts_notmergedTR_Healthy1_Organoid..._1.txt.gz GSM2653834_Counts_notmergedTR_Healthy1_Organoid_2.txt.gz GSM2653835_Counts_notmergedTR_Healthy2..._Organoid.txt.gz GSM2653837_Counts_notmergedTR_Healthy3_Organoid.txt.gz 详细的样品分布如下所示： > table(colD)...cancer group CC CHC HCC Healthy Organoid 7 5 3 6 Tissue 4 3 3
of DNA Repair Inhibitor Response in Short Term Patient-Derived Ovarian Cancer Organoids 研究者共成功制备了33 organoid...Heat map of five independent organoid lines from both early and late passages based on 11,720 methylation...Siggia）https://science.sciencemag.org/content/364/6444/948 Cancer modeling meets human organoid technology
Trends in the global organoid technology and industry: from organogenesis in a dish to the commercialization...Organoid 2021;1:e11.5. Kai Kretzschmar, Hans Clevers....Progress and potential in organoid research. Nat Rev Genet. 2018 Nov;19(11):671-687.10....The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19.
个重要的探索样品了 ： BoML: bone metastasis left pelvis, BoMR: bone metastasis right tibia, PDOL/R: patient-derived organoid...left/right (bone metastasis), PDOX: patient-derived organoid xenograft 两个转移样品跟原位肿瘤差异 主要是从肿瘤外显子的somatic
英国研究团队在实验室成功培养出第一个人类原发性肝癌的迷你生物模型，这项也称为「类器官」（organoid）的模型已应用于测试数种癌症用药，包括现行癌症治疗用药及研发中癌症新药，初步结果相当令人振奋。...此项研究的主持人之一Meritxell Huch 博士说，「我们之前曾利用健康肝脏组织成功创造出类器官（organoid），但这次类肿瘤（tumouroid）的创造对肝癌研究又更推进了一大步。...2017-Brca1-mutation-mouse-orgnoids 使用类器官（Organoid）进行药物研发是类器官的重要应用方向。...类器官（Organoid）是把干细胞在体外3D条件下培养，产生的“类似”器官样的结构。类器官具有广泛的用途，可以用作各种疾病模型，在肿瘤研究精准医学研究中具有重要意义。
., Identification of multipotent luminal progenitor cells in human prostate organoid cultures....Cell, 2015. 160(1-2): p. 299-312. 14.Boj, S.F., et al., Organoid models of human and mouse ductal pancreatic...2018. 172(1-2): p. 373-386 e10. 18. van de Wetering, M., et al., Prospective derivation of a living organoid...Nat Commun, 2017. 8: p. 14262. 21.Fujii, M., et al., A Colorectal Tumor Organoid Library Demonstrates
针对人类癌症模型计划的NCI癌症模型开发 TCGA-CHOL Cholangiocarcinoma 胆管癌 TCGA-KIRC Kidney Renal Clear Cell Carcinoma 肾肾透明细胞癌 ORGANOID-PANCREATIC...Pancreas Cancer Organoid Profiling 胰腺癌类器官分析 TCGA-BRCA Breast Invasive Carcinoma 乳腺浸润癌 TCGA-OV Ovarian
文章发表于stem.2018.09.016，标题是：A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype...Heterogeneity and Enables Therapeutic Screening 本研究主要是完成了一个 a primary gastric cancer organoid (GCO)
Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid
Organogenesis in a dish: modeling development and disease using organoid technologies....Organoid technology and applications in cancer research. J Hematol Oncol 11, 116 (2018). 12.
Organoids as a Platform for Drug Screening》的研究成果，也是这样的展现： 首先看：A) Somatic genomic landscape of 15 UTUC organoid
还加入了当下最热门的话题：CHatGPT 以及类器官 Organoid 相关词条。
领取专属 10元无门槛券
手把手带您无忧上云
云服务器
ICP备案
实时音视频
对象存储
即时通信 IM
