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一道线程同步面试题

sub: 1 of loop 1 sub: 2 of loop 1 sub: 3 of loop 1 sub: 4 of loop 1 sub: 5 of loop 1 sub: 6 of loop 1 sub: 7 of loop 1 sub: 8 of loop 1 sub: 9 of loop 1 sub: 10 of loop 1 main: 1 of loop 1 main: 2 of loop 1 main: 3 of loop 1 main: 4 of loop 1 main: 5 of loop 1 sub: 1 of loop 2 sub: 2 of loop 2 sub: 3 of loop 2 sub: 4 of loop 2 sub: 5 of loop 2 sub: 6 of loop 2 sub: 7 of loop 2 sub: 8 of loop 2 sub: 9 of loop 2 sub: 10 of loop 2 main: 1 of loop 2 main: 2 of loop 2 main: 3 of loop 2 main: 4 of loop 2 main: 5 of loop 2 sub: 1 of loop 3 sub: 2 of loop 3 sub: 3 of loop 3 sub: 4 of loop 3 sub: 5 of loop 3 sub: 6 of loop 3 sub: 7 of loop 3 sub: 8 of loop 3 sub: 9 of loop 3 sub: 10 of loop 3 main: 1 of loop 3 main: 2 of loop 3 main: 3 of loop 3 main: 4 of loop 3 main: 5 of loop 3 sub: 1 of loop 4 sub: 2 of loop 4 sub: 3 of loop 4 sub: 4 of loop 4 sub: 5 of loop 4 sub: 6 of loop 4 sub: 7 of loop 4 sub: 8 of loop 4 sub: 9 of loop 4 sub: 10 of loop 4 main: 1 of loop 4 main: 2 of loop 4 main: 3 of loop 4 main: 4 of loop 4 main: 5 of loop 4 sub: 1 of loop 5 sub: 2 of loop 5 sub: 3 of loop 5 sub: 4 of loop 5 sub: 5 of loop 5 sub: 6 of loop 5 sub: 7 of loop 5 sub: 8 of loop 5 sub: 9 of loop 5 sub: 10 of loop 5 main: 1 of loop 5 main: 2 of loop 5 main: 3 of loop 5 main: 4 of loop 5 main: 5 of loop 5 sub: 1 of loop 6 sub: 2 of loop 6 sub: 3 of loop 6 sub: 4 of loop 6 sub: 5 of loop 6 sub: 6 of loop 6 sub: 7 of loop 6 sub: 8 of loop 6 sub: 9 of loop 6 sub: 10 of loop 6 main: 1 of loop 6 main: 2 of loop 6 main: 3 of loop 6 main: 4 of loop 6 main: 5 of loop 6 sub: 1 of loop 7 sub: 2 of loop 7 sub: 3 of loop 7 sub: 4 of loop 7 sub: 5 of loop 7 sub: 6 of loop 7 sub: 7 of loop 7 sub: 8 of loop 7 sub: 9 of loop 7 sub: 10 of loop 7 main: 1 of loop 7 main: 2 of loop 7 main: 3 of loop 7 main: 4 of loop 7 main: 5 of loop 7 sub: 1 of loop 8 sub: 2 of loop 8 sub: 3 of loop 8 sub: 4 of loop 8 sub: 5 of loop 8 sub: 6 of loop 8 sub: 7 o

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NAR | 陈加余/陈亮合作建立R-loop全基因组分布与调控的专家数据库

R-loop是由RNA:DNA杂合链和非模板单链DNA构成的三链结构,广泛存在于从细菌到人类等物种的基因组中。R-loop结构主要随细胞转录活动产生,受细胞精细调控而处于高度动态变化当中。生理水平下的R-loop结构密切参与转录调控、组蛋白与DNA的表观遗传修饰调控、DNA损伤修复、免疫球蛋白类型转换等生物学过程,并作为调控网络的一环,与蛋白因子协同发挥着重要的调控作用。另一方面,R-loop调控异常会造成染色质状态改变,基因转录失调和基因组稳定性下降等。研究表明R-loop调控蛋白的突变与R-loop的异常积累是导致神经退行性疾病、癌症、自身免疫性疾病等的潜在诱因之一。

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