blocks|key|3064531|text|此错误是由以管理员身份运行的visual+studio引起的。Outlook不允许单独的用户访问同一邮箱(我在桌面上打开了outlook应用程序)。即使我拥有域用户的本地管理员访问权限，以管理员身份运行VS也必须将进程关联到不同的用户对象？不太确定这是怎么回事，但是...已解决。|type|unstyled|depth|inlineStyleRanges|entityRanges|data|3064532|entityMap^0|0^^$0|@$1|2|3|4|5|6|7|D|8|@]|9|@]|A|$]]|$1|B|3|-4|5|6|7|E|8|@]|9|@]|A|$]]]|C|$]]

This error was caused by visual studio being run as admin. Outlook doesn't allow separate users to access the same mailbox (I had the outlook application open on desktop). Even though I have local admin access w/ my domain user, running VS as admin must associate the process to a different user object? Not exactly sure how this works, but... Resolved.

blocks|key|3064560|text|我遇到了同样的问题，正如前面所说的:如果Visual+Studio是以管理员身份运行的，则Outlook会阻止另一个具有不同用户的实例。我的VS解决方案正在启动几个项目，我需要它以管理员身份运行，所以我所做的就是在调试时以管理员身份运行Outlook。这解决了我的问题。|type|unstyled|depth|inlineStyleRanges|entityRanges|data|3064561|entityMap^0|0^^$0|@$1|2|3|4|5|6|7|D|8|@]|9|@]|A|$]]|$1|B|3|-4|5|6|7|E|8|@]|9|@]|A|$]]]|C|$]]

I ran into the same issue, and as previously said: if Visual Studio is running as Administrator then Outlook prevents another instance with a different user. My VS solution is starting several projects, and I need it to run as Administrator, so what I did is run Outlook as administrator while debugging. This solved my problem.

blocks|key|3064667|text|发布其中一条评论作为答案。|type|unstyled|depth|inlineStyleRanges|entityRanges|data|3064668|3064669|当我们关闭正在运行的Outlook实例时，它就像一个护身符。|blockquote|3064670|3064671|3064672|在我的情况下，我在带有特殊安全软件的VM下运行。在我的开发人员桌面上，当Outlook打开时，它工作得很好。|3064673|但在我的安全虚拟机中，我不得不关闭outlook才能让它正常工作。这很可能是因为我们的安全软件。|3064674|当outlook保持运行时：Unhandled+Exception:+System.Runtime.InteropServices.COMException:+Retrieving+the+COM+class+factory+for+component+with+CLSID+{0006F03A-0000-0000-C000-000000000046}+failed+due+to+the+following+error:+80080005+Server+execution+failed+(Exception+from+HRESULT:+0x80080005+(CO_E_SERVER_EXEC_FAILURE)).|offset|length|style|CODE|3064675|当它不运行时，它工作得很好。|3064676|entityMap^0|0|0|0|0|0|0|0|E|87|0|0^^$0|@$1|2|3|4|5|6|7|V|8|@]|9|@]|A|$]]|$1|B|3|-4|5|6|7|W|8|@]|9|@]|A|$]]|$1|C|3|D|5|E|7|X|8|@]|9|@]|A|$]]|$1|F|3|-4|5|6|7|Y|8|@]|9|@]|A|$]]|$1|G|3|-4|5|6|7|Z|8|@]|9|@]|A|$]]|$1|H|3|I|5|6|7|10|8|@]|9|@]|A|$]]|$1|J|3|K|5|6|7|11|8|@]|9|@]|A|$]]|$1|L|3|M|5|6|7|12|8|@$N|13|O|14|P|Q]]|9|@]|A|$]]|$1|R|3|S|5|6|7|15|8|@]|9|@]|A|$]]|$1|T|3|-4|5|6|7|16|8|@]|9|@]|A|$]]]|U|$]]

Posting one of the comments as an answer.
<blockquote>
When we close the running instance of Outlook it works like a charm.
</blockquote>
In my situation I'm running under VMs with special security software. On my developer desktop it worked fine when Outlook was open.
But in my secured VM I had to close outlook in order to get this to work. This is likely to due our security software.
When outlook is left running: <code>Unhandled Exception: System.Runtime.InteropServices.COMException: Retrieving the COM class factory for component with CLSID {0006F03A-0000-0000-C000-000000000046} failed due to the following error: 80080005 Server execution failed (Exception from HRESULT: 0x80080005 (CO_E_SERVER_EXEC_FAILURE)).</code>
When it is not running, it works fine.

blocks|key|3064733|text|公认的答案并不完全准确。实际上，如果调用应用程序不具有与原始进程相同的访问级别，则COM将失败。两者需要处于相同的访问级别。|type|unstyled|depth|inlineStyleRanges|entityRanges|data|3064734|因此，如果Outlook是以管理员身份启动的，并且在Visual+Studio中调试的程序也是以管理员身份启动的，那么它将正常工作。|3064735|Vica-反之亦然:如果Outlook不是以管理员身份启动的，则在Visual+Studio中调试的程序也需要是非管理员身份。|3064736|此外，如果没有包含Microsoft.Office.Core的COMReference，您也可以收到此消息。|offset|length|style|CODE|3064737|entityMap^0|0|0|0|9|L|V|C|0^^$0|@$1|2|3|4|5|6|7|N|8|@]|9|@]|A|$]]|$1|B|3|C|5|6|7|O|8|@]|9|@]|A|$]]|$1|D|3|E|5|6|7|P|8|@]|9|@]|A|$]]|$1|F|3|G|5|6|7|Q|8|@$H|R|I|S|J|K]|$H|T|I|U|J|K]]|9|@]|A|$]]|$1|L|3|-4|5|6|7|V|8|@]|9|@]|A|$]]]|M|$]]

The accepted answer is not entirely accurate. Actually, the COM will fail if the calling application does NOT have the same access level as the original process. Both need to be at the same access level.
So, if Outlook was started as Administrator and the program being debugged in Visual Studio is also administrator, it will work.
Vica-versa: if Outlook was NOT started as Administrator, then the program being debugged in Visual Studio will also need to be NON-administrator.
Also, you can get this message if not also included a <code>COMReference</code> to <code>Microsoft.Office.Core</code>.

I have an application that calls

<pre><code>Email hello = new Email(appropriate constructor);
hello.Email_Send();
</code></pre>

I'm receiving the exception:

<blockquote>
 Retrieving the COM class factory for component with CLSID {0006F03A-0000-0000-C000-000000000046} failed due to the following error: 80080005 Server execution failed (Exception from HRESULT: 0x80080005 (CO_E_SERVER_EXEC_FAILURE)).
</blockquote>

from <code>System.Runtime.InteropServices.COMException</code>.

<pre><code>using O = Microsoft.Office.Interop.Outlook; 
class Email
{
 public void Email_Send()
 {
 O.Application outlook = new O.Application(); //Exception thrown here.
 O.MailItem message = outlook.CreateItem(O.OlItemType.olMailItem);
 message.To = Receiver;
 message.CC = Sender;
 message.Subject = Subject;
 message.Body = "This is an automated message sent at " + DateTime.Now.ToString("HH:mm:ss") + " about " + Body_Topic + System.Environment.NewLine + Body_Content ;
 message.Send();
 }
}
</code></pre>

This error has never happened previously, and there has been no change to the code that I know of. <a href="http://support.microsoft.com/kb/825118">http://support.microsoft.com/kb/825118</a> doesn't seem to fit the my symptoms - My computer doesn't stop responding, etc.
Any help diagnosing the issue would be greatly appreciated!

Why am I receiving exception from Office's Outlook library?

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我有一个应用程序调用Email hello = new Email(appropriate constructor);hello.Email_Send();我收到了一个异常：由于以下错误，检索CLSID为{0006F03A-0000-0000-C000-000000000046}的组件的COM类工厂失败: 800800...

问为什么我从Office的Outlook库中收到异常？
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