var str = "Hello,World;JavaScript|Node.js";
var separators = [",", ";", "|"];
var result = str.split(separators);
console.log(result);

var str = "Hello,World;JavaScript|Node.js";
var separators = [",", ";", "|"];
var separator = "@";
var result = str.replace(new RegExp(separators.join("|"), "g"), separator).split(separator);
console.log(result);

var str = "Hello,World;JavaScript|Node.js";
var separators = [",", ";", "|"];
var result = [];
var start = 0;
var end = 0;
for (var i = 0; i < separators.length; i++) {
  end = str.indexOf(separators[i]);
  if (end !== -1) {
    result.push(str.substring(start, end));
    start = end + 1;
  }
}
result.push(str.substring(start));
console.log(result);