【直播】 致知讲堂第50期 | 西班牙巴塞罗那基因组调控中心Maria Pia Cosma教授精彩开讲

致知讲堂

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“致知讲堂”系中国科学院深圳先进技术研究院下属深圳合成生物学创新研究院秉持“造物致知、造物致用”的理念打造的开放性学术会议，以开放共享的形式共促领域内交流合作。讲堂定期特邀合成生物学及相关领域海内外知名学者专家进行学术报告，聚焦发展前沿，探讨学术热点，致力于打造合成生物学开放型学术交流平台，为合成生物学发展助力。

本期讲座

我们邀请到了

西班牙巴塞罗那基因组调控中心

Maria Pia Cosma教授

为大家带来关于

“Super Resolution Imaging and Modelingto Uncover 3D Genome Organizationand Chromatin Looping”主题的演讲

讲座安排

主讲人: Maria Pia Cosma 教授

主持人:  胡政 研究员

时 间: 2025年10月24日 上午10:00-11:45

地 点:D6环形报告厅 ( 深圳先进院 )

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Abstract

Dissecting the 3D-chromatin organization in cell physiology is a key area of investigation. By using quantitative super-resolution nanoscopy, we identified a novel chromatin fiber assembly and its relation with naïve pluripotency. Nucleosomes are arranged in groups of various sizes, the nucleosome clutches, which control gene function. Recently, by combining imaging and genomic approaches, we designed MiOS, a powerful integrated strategy to model the folding of key pluripotency genes at nucleosome resolution and identified the chromatin structure surrounding them at early stages of embryo development. We also recently visualized the structure of cohesin-mediated loops in human cells and discovered that transcriptional-dependent supercoiling controls loop formation and 3D-genome organization. Currently we are studying how topoisomerase activity controls supercoiling-dependent chromatin folding.

Overall, super-resolution microscopy combined with genomic and modeling methods allowed us to dissect the functional role of transcription-mediated supercoiling and the nucleosome level structure of genes, which ultimately are key features controlling cell function.

Maria Pia Cosma

Biography

Professor Maria Pia Cosma is a research Professor at the Center for Genomic Regulation (CRG) in Barcelona, Spain, also holds a PI position at Guangdong Provincial People’s Hospital (GDPH) in Guangzhou now.

From 1997 to 2000, she was a Marie Curie Fellow at the Research Institute of Molecular Pathology (IMP) in Vienna, and in 2000 she became a postdoctoral fellow at the Telethon Institute of Genetics and Medicine (TIGEM) in Naples. From 2004 to 2010, she was a Lecturer at the European School of Molecular Medicine, and from 2009 to 2015, she served as an Honorary Associate Investigator at the Institute of Genetics and Biophysics (IGB) in Naples. In April 2010, she moved to Barcelona, Spain, to join the Centre for Genomic Regulation (CRG) as a Senior Scientist and Catalan Institution for Research and Advanced Studies (ICREA) Research Professor. In 2025, she was elected Acadèmica Corresponent of the Reial Acadèmia de Medicina de Catalunya. Since 2024, she has been the Coordinator of the Systems and Synthetic Biology Program at CRG.

She has delivered numerous invited talks at major international conferences and research institutes and has received several prestigious awards, including the Marie Curie Excellence Award (2005), the Order of Merit of the Italian Republic (2007), election as an EMBO Member (2010), the Barcelona City Prize (2015), EIC National Champion (2021), and the EIC Woman Leadership Programme Award (2022). She has been awarded major research grants, including an ERC Grant (2009) and a Human Frontier Science Program (HFSP) Grant (2010), and has coordinated European Innovation Council (EIC) projects, including Cellviever (2016) and EcaBox (2021).

Co-organized by

定量合成生物学全国重点实验室

State Key Laboratory of Quantitative Synthetic Biology

中国科学院深圳先进技术研究院合成生物学研究所

Institute of Synthetic Biology, SIAT, CAS

深圳理工大学合成生物学院

Faculty of Synthetic Biology,SUAT

深圳合成生物学创新研究院

Shenzhen Institute of Synthetic Biology